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Minocycline HCL

Minocycline hydrochloride

CAS: 13614-98-7

Molecular Formula: C23H28ClN3O7

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Minocycline HCL - Names and Identifiers

Name Minocycline hydrochloride
Synonyms Minocyclin HCl
Minocycline HCL
Minocycline hydrochloride
Minocycline hydrochloride Solution, 100ppm
10,12,12a-tetrahydroxy-1,11-dioxo--monohydrochloride
KlinoMycin, Minocycline chloride, MinoMycin, NSC 141993
[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-te
4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
2-(Amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione hydrochloride
(4S,4aS,5aR,12aS)-4,7-Bis(diMethylaMino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxaMide hydrochloride
(2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
(2E,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
(4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
CAS 13614-98-7
EINECS 237-099-7
InChI InChI=1/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChIKey GLMUAFMGXXHGLU-VQAITOIOSA-N

Minocycline HCL - Physico-chemical Properties

Molecular FormulaC23H28ClN3O7
Molar Mass493.94
Melting Point205-210° (dec)
Boling Point813℃
Flash Point>110°(230°F)
Water SolubilityFreely soluble in water
Solubility water: 50 mg/mL
Vapor Presure6.33E-28mmHg at 25°C
AppearanceTender yellow to orange amorphous solid
Coloryellow
Merck14,6202
Storage Condition2-8°C
StabilityLight Sensitive
SensitiveSensitive to light
MDLMFCD00083669
Physical and Chemical PropertiesYellow crystalline powder. Soluble in water, light unstable, bitter taste. The base [10118-90-8] was a bright yellow amorphous solid.

Minocycline HCL - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
UN IDs3249
WGK Germany3
RTECSQI7630500
HS Code29413020
Hazard Class6.1(b)
Packing GroupIII

Minocycline HCL - Reference

Reference
Show more
1. [IF=6.17] Qian Huang et al."Cynandione A attenuates neuropathic pain through p38β MAPK-mediated spinal microglial expression of β-endorphin."Brain Behav Immun. 2017 May;62:64
2. [IF=4.36] Qian Huang et al."Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors."J Ethnopharmacol. 2017 Jan;196:151
3. [IF=8.322] Apryani Evhy et al."The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors."J Neuroinflamm. 2020 Dec;17(1):1-18
4. [IF=7.217] Khalil Ali Ahmad et al."Microglial IL-10 and β-endorphin expression mediates gabapentinoids antineuropathic pain."Brain Behav Immun. 2021 Jul;95:344
5. [IF=5.858] Meng-Yan Deng et al."Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway."Biochem Pharmacol. 2021 Oct;192:114727
6. [IF=5.81] Zhao Meng-Jing et al."Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression."Front Pharmacol. 2021 Feb;0:92
7. [IF=5.243] Le Ma et al."Spinal microglial β‐endorphin signaling mediates IL‐10 and exenatide‐induced inhibition of synaptic plasticity in neuropathic pain."Cns Neurosci Ther. 2021 Oct; 27(10): 1157–1172
8. [IF=4.545] Usman Ali et al."Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway."Biomed Pharmacother. 2020 May;125:109898
9. [IF=4.223] Yuan et al."Efficient degradation of minocycline by natural bornite-activated hydrogen peroxide and persulfate: kinetics and mechanisms."Environmental Science And Pollution Research. 2021 Jul 22
10. [IF=3.599] Ma Le et al."Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses."Neural Plast. 2021;2021:9923537
11. [IF=3.575] Xueqi Tang et al."The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and β-endorphin."Biochem Bioph Res Co. 2020 Sep;530:494
12. [IF=3.093] Huang Sheng-Nan et al."Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A."Neural Plast. 2020;2020:1484087
13. [IF=3.631] Zhiya Yang et al."5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum."Photodiagn Photodyn. 2022 Mar;:102839

Minocycline HCL - Standard

Authoritative Data Verified Data

This product is [4S-(4a,4aa,5aa,12aa) ]-4, 7-bis (-methyl chloride)-1,4,4a,5,5a,6,11, 12a-octahydro-3, 10,12, 12a-tetrahydroxy-1, 11-dioxo-2-and tetrabenzamide hydrochloride. Minocycline (C23H27N307) should be present in the range of 89.0% to 95.0%, calculated as anhydrous.

Last Update：2024-01-02 23:10:35

Minocycline HCL - Trait

Authoritative Data Verified Data
  • This product is yellow crystalline powder; Odorless; With hygroscopicity.
  • This product is dissolved in methanol, slightly soluble in water, slightly soluble in ethanol, almost insoluble in ether.
Last Update：2022-01-01 15:04:10

Minocycline HCL - Introduction

Soluble in water, unstable when exposed to light, bitter taste.
Last Update：2022-10-16 17:13:38

Minocycline HCL - Differential diagnosis

Authoritative Data Verified Data
  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 825).
  3. the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:04:10

Minocycline HCL - Exam

Authoritative Data Verified Data

crystallinity

take this product, according to the law inspection (General 0981), should comply with the provisions.

acidity

take this product, add water to make a solution containing lOmg per lml, and determine it according to law (General 0631). The pH value should be 3.5~4.5.

Related substances

operation in the dark, ready to use the new system. Take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 0.5mg of minocycline per 1 ml, as a test solution; Take an appropriate amount of precision, A solution containing about 5ug of minocycline per 1 ml was prepared as a control solution by quantitative dilution with water. According to the chromatographic conditions under the item of content determination, each lol of the test solution and the control solution is accurately weighed and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 2.6 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the peak area of the differential minocycline shall not be greater than 1.2 times (1.2%) of the main peak area of the control solution, the Peak area of other single impurities shall not be greater than 1.2 times (1.2%) of the main peak area of the control solution, and the sum of the peak areas of other impurities shall not be greater than 2 times (2.0%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.05 times smaller than the main peak area of the control solution were ignored.

moisture

take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 4.3% ~ 8.0%.

ignition residue

not more than 0.5% (General rule 0841).

Heavy metals

The residue left under the item of ignition residue shall not contain more than 0821 parts per million of heavy metal after examination by law (General Chapter, Law II).

Last Update：2022-01-01 15:04:11

Minocycline HCL - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

octanosilane-bonded silica gel as filler; 0.2mol/L ammonium acetate-dimethylformamide-tetrahydrofuran (600:398:2, containing 0.0 mol/L ethylene diamine tetraacetic acid disodium) mobile phase; The detection wavelength was 280nm. Take about 10mg of minocycline hydrochloride reference, put it in a 25ml measuring flask, add 5ml of water to dissolve it, heat it in a boiling water bath for 60 minutes, cool it, dilute it to the scale with water, shake well, and inject 10u1 into the liquid chromatograph, when the chromatogram is recorded, the tailing factor of minocycline peak should be between 0.9 and 1.35, and the separation degree between minocycline peak and minocycline peak (relative retention time is about 0.8) should be greater than 2.5.

assay

take an appropriate amount of this product (about 50mg equivalent to minocycline), accurately weigh it, put it in a 100ml measuring flask, add water to dissolve and dilute to the scale, shake well, and use it as a test solution, immediately take 10u1 injection liquid chromatograph, record chromatogram; Take appropriate amount of minocycline reference substance, determine with the same method, calculate the content of C23H27N307 in the test sample by peak area according to external standard method.

Last Update：2022-01-01 15:04:12

Minocycline HCL - Category

Authoritative Data Verified Data

tetracyclic antibiotics.

Last Update：2022-01-01 15:04:12

Minocycline HCL - Storage

Authoritative Data Verified Data

light shielding and sealed storage.

Last Update：2022-01-01 15:04:12

Minocycline HCL - Minocycline Hydrochloride Tablets

Authoritative Data Verified Data

This product contains minocycline hydrochloride by minocycline (C23H27N307), should be 90.0% to 110.0% of the label.

trait

This product is yellow tablet or sugar-coated tablet or film-coated tablet, yellow after removing the coating.

identification

  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. take an appropriate amount of fine powder of this product (equivalent to 20mg of minocycline), add water 20ml, shake to dissolve minocycline hydrochloride, filter, filtrate chloride to identify (1) reaction (General 0301).

examination

  • the related substances were operated in the dark, and the new system was ready for use. Take 10 tablets of this product, grind, weigh an appropriate amount accurately, add water to dissolve and dilute to make a solution containing about 0.5mg minocycline per 1 ml, filter, and take the continued filtrate as the test solution, test according to the method under minocycline hydrochloride, should be consistent with the provisions.
  • water content: take an appropriate amount of the fine powder of this product and determine the moisture content according to the method of moisture determination (General rule 0832, first method 1). The moisture content shall not exceed 12.0%.
  • the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, at 45 minutes, the solution is suitably Halo, filtered, and the appropriate amount of filtrate is accurately taken and diluted quantitatively with water to make a solution containing about 15ug of minocycline per lml, according to UV-visible spectrophotometry (General rule 0401), measure absorbance at the wavelength of 348nm; Take appropriate amount of minocycline reference substance, water was added to dissolve and quantitatively diluted to prepare a solution containing about 15ug per 1 ml, which was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 10 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 50mg equivalent to minocycline), put it in a 100ml measuring flask, add water 80ml, ultrasound for 5 minutes, dilute to scale with water, shake, filter, and take the filtrate as a test solution. According to the method under the item of minocycline hydrochloride, obtained.

category

with minocycline hydrochloride.

specification

Based on C23H27N307 (l)50mg (2)100Mg

storage

light shielding, sealed storage.

Last Update：2022-01-01 15:04:13

Minocycline HCL - Minocycline Hydrochloride Cap

Authoritative Data Verified Data

This product contains minocycline hydrochloride by minocycline (C23H27N3O7) calculation, should be 90.0% ~ 110.0% of the label amount.

trait

The contents of this product are yellow to dark yellow powder or granules; Or yellow to yellow brown pellets.

identification

  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. take an appropriate amount of the content of this product (equivalent to minocycline 20mg), finely grind, add water 20ml, shake to dissolve minocycline hydrochloride, filter, filtrate chloride identification (1) reaction (General 0301).

examination

  • the related substances were operated in the dark, and the new system was ready for use. Take the contents under the item of difference in loading amount, grind them finely, weigh them properly, dissolve them with water and dilute them to make a solution containing about 0.5mg of minocycline per 1 ml, and filter them through, take the continued filtrate as the test solution, test according to the method under the item of minocycline hydrochloride, and the peak area of the differential minocycline shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution, the Peak area of other single impurities shall not be greater than 1.2 times (1.2%) of the main peak area of the control solution, and the sum of the peak areas of other impurities shall not be greater than 2.0 times (2.0%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.05 times smaller than the main peak area of the control solution were ignored.
  • moisture the content of this product is extracted, ground, and measured by the method of moisture determination (General rule 0832, Method 1). The moisture content shall not exceed 12.0%.
  • the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, 45 minutes, take the appropriate amount of solution, filtration, precision take the appropriate amount of filtrate, quantitative dilution of water to make a solution containing about 15ug of minocycline per lml, according to UV-visible spectrophotometry (General rule 0401), measure absorbance at the wavelength of 348nm; Take appropriate amount of minocycline reference substance, water was added to dissolve and quantitatively diluted to prepare a solution containing about 15ug per 1 ml, which was determined by the same method, and the dissolution amount of each particle was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions. (The content is powder or granule) take this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed is 50 rpm, according to the law, at 30 minutes, take the appropriate amount of solution, filter, take the appropriate amount of filtrate, dilute it quantitatively with water to make a solution containing minocycline in about 15g/mL, and make up the same volume of isothermal dissolution medium in time; at 60 minutes, take the appropriate amount of solution, filter, take the appropriate amount of filtrate, dilute with water quantitatively to make a solution containing about 15ug of minocycline per lml, according to UV-visible spectrophotometry (General rule 0401), measure absorbance at the wavelength of 348nm; Take appropriate amount of minocycline reference substance, water was added to dissolve and quantitatively diluted to prepare a solution containing about 15ug per 1 ml, which was determined by the same method, and the dissolution amount of each particle was calculated. The limit at 30 minutes is 35% of the labeled amount and at 60 Minutes is 60% of the labeled amount. (The content is pellets)
  • others should comply with the relevant provisions under the capsule (General 0103).

Content determination

appropriate amount of content (about 50mg equivalent to minocycline) under the item of difference in loading amount was removed, ground, accurately weighed, put it into a 100ml measuring flask, add 80ml of water, and sonicate to dissolve minocycline hydrochloride, dilute to scale with water, shake, filter, and take the filtrate as a test solution. According to the method under the item of minocycline hydrochloride, obtained.

category

with minocycline hydrochloride.

specification

Based on C23H27N307 (l)50mg (2)100Mg

storage

light shielding, sealed storage.

Last Update：2022-01-01 15:04:14
Minocycline HCL
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CAS: 13614-98-7
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Shanghai Yuanye Bio-Technology Co., Ltd.
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Minocycline hydrochloride Visit Supplier Webpage Request for quotation
CAS: 13614-98-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple Specifications
Product Name: Minocycline Hydrochloride Request for quotation
CAS: 13614-98-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Minocycline hydrochloride Request for quotation
CAS: 13614-98-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Minocycline HCL
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